Glibenclamide Sodium Salt (Glyburide Sodium)Manufacturer in India
For anti-diabetic drug makers who want no surprises at incoming QC: Glibenclamide Sodium Salt with HPLC purity of NLT 99.0%, from PYG Lifesciences Pvt. Ltd.
4'-Bromomethyl-2-cyanobiphenyl
Glibenclamide Sodium Salt
5-Chloro-N-[3-cyclohexylureidosulfonylphenethyl]-2-methoxybenzamide Monosodium
- CAS No.: 10238-21-8
- Molecular formula:C₂₃H₂₇ClN₃NaO₅S
- Molecular Weight: 516.0 g/mol (approx.)
- Class: Second-generation sulfonylurea antidiabetic
- Therapeutic uses: Type 2 diabetes mellitus
- Appearance: White to off-white powder or cream color powder
- Storage: Tightly closed, cool and dry, away from acids and oxidizers
Product overview
Glibenclamide Sodium Salt (C₂₃H₂₇ClN₃NaO₅S) is the mono sodium salt of Glibenclamide (Glyburide), a second-generation sulfonylurea antidiabetic used in the treatment of type 2 diabetes mellitus. It is also known as Glyburide sodium, Glibenclamide Na, Na-GBC and Chic Salt, and is referred to by some buyers as a Glibenclamide Sodium Salt intermediate.
As an API intermediate manufacturer in India, PYG Lifesciences supplies Glibenclamide Sodium Salt to pharmaceutical companies for manufacturing and research applications. Each lot is tested by HPLC and produced under our ISO 9001:2015 quality management system, with batch documentation that supports straightforward supplier qualification.
Key Applications of Glibenclamide Sodium Salt
Where does Glibenclamide Sodium Salt earn its place? Wherever teams are building, developing or testing Glibenclamide-based medicines.
Anti-Diabetic Drug Manufacturing
Production teams working with Glibenclamide (Glyburide) need a well-defined sodium salt they can plan their processes around. That's exactly what we set out to supply.
Pharmaceutical R&D
Formulation and process chemists use it to explore and refine Glibenclamide-based products. They start from a material with a clear, documented specification.
Quality Control & Analytical Work
QC labs get what they need to verify each lot. A batch COA comes as standard, and the SDS and MOA are there whenever they're asked for.Pharmaceutical Intermediates for Anti-Diabetic Portfolios
It sits alongside other pharmaceutical intermediates used in Glibenclamide work, such as Glibenclamide Sulfonamide, for companies building or extending an anti-diabetic product range.
Supporting Glibenclamide-based type 2 diabetes treatments, from R&D to production.
Technical Specifications of Glibenclamide Sodium Salt
| Sr. No. | Property | Details |
| 1 | Chemical Name | Glibenclamide Sodium Salt (5-Chloro-N-[3-cyclohexylureidosulfonylphenethyl]-2-methoxybenzamide Monosodium) |
| 2 | CAS Number | 10238-21-8 |
| 3 | Molecular Formula | C₂₃H₂₇ClN₃NaO₅S |
| 4 | Molecular Weight | 516.0 g/mol (approx.) |
| 5 | Physical Form | White to off-white to cream color solid / crystalline / powder |
| 6 | Assay (HPLC) | NLT 99.0% |
| 7 | Purity (HPLC) | NLT 90.0% |
| 8 | Documents Available | COA, SDS, MOA on request |
Batch-specific results are reported on the Certificate of Analysis (COA) supplied with each shipment.
| Specification | Details |
|---|---|
| Chemical Name | Bromo-OTBN (4’-Bromomethyl-2-cyanobiphenyl) |
| Synonyms | As used in client-specific synthetic routes |
| CAS Number | 114772-54-2 |
| Molecular Formula & Weight | C₁₄H₁₀BrN/272.14 g/mol |
| Appearance | Off-white to white powder with a fine consistency, optimized for ease of use in your processes. |
| Assay (HPLC) | NLT 98.0% (typical ≥99.0%) |
| Related Substances (HPLC) | Each ≤0.15%, total ≤0.50% or per customer-approved spec |
| Residual Solvents (GC) | In compliance with ICH Q3C |
| Water (KF) | ≤0.5–1.0% depending on processing and packaging |
| Melting Range | Provided on request |
| Retest Period | Up to 24 months under original sealed conditions (subject to stability data) |
| HS Code | Available upon request |
| Analytical Documentation | Complete IR, ¹H/¹³C NMR, MS, method summaries, impurity rationale, and stability data available under CDA/NDA |
| Grade | Industrial grade as per specification available. COA will be shared on request |
| Purity | Each batch is tested in our well-equipped QC laboratory by skilled analysts, following established SOPs and protocols. We ensure that the final product meets purity with rigorous QA oversight before shipment. |
| Stability | Stable under recommended storage conditions. We advise storage in a cool, dry environment away from direct sunlight. |
Key Safety Information
- Main pharmacological hazard: hypoglycemia (sweating, tremor, confusion; seizures in severe cases)
- Harmful if swallowed
- Suspected reproductive toxicity (H361)
- Possible target-organ effects on repeated exposure
- Alkaline salt: irritant to skin, eyes and respiratory tract. Fine dust is the main exposure route
Glibenclamide Sodium Salt is supplied for industrial pharmaceutical manufacturing and research use only. It is not meant for direct medicinal or human use. Please refer to the product SDS for complete hazard and emergency details.
Safety Precaution
- Engineering controls: Closed charging; filter-dryer or centrifuge discharge under LEV; a contained or ventilated area for powder handling
- PPE: Dust respirator (P3/FFP3, or PAPR for open handling), double nitrile gloves, goggles, coverall and shoe covers
- Personnel: Keep pregnant or nursing staff, and diabetics on sulfonylureas, away from open handling. Restrict access to trained operators
- Hygiene: No eating or drinking in the area. Wash and change before leaving
- Spills: Wet-wipe or HEPA-vacuum, never dry sweep, and collect as hazardous waste
- Storage: Tightly closed, cool and dry, away from acids and oxidizers
- First aid (skin / eye): Rinse with water for 15 minutes
Frequently Asked Questions (FAQs)
What exactly is Glibenclamide Sodium Salt (Glyburide Sodium)?
It’s the mono sodium salt of Glibenclamide (Glyburide), the second-generation sulfonylurea used in type 2 diabetes. On quotes and documents it may also appear under one of its synonyms, which are listed in the specification table above.
Which CAS number applies to Glibenclamide Na?
10238-21-8 is the CAS number usually quoted, but it belongs to the parent compound, Glibenclamide. Because it doesn’t separate the salt from the parent on its own, check the molecular formula on any quotation. The sodium salt carries Na in its formula.
Does it need special handling?
Yes. It’s pharmacologically active, so accidental exposure can lower blood sugar, and its fine alkaline dust irritates the skin, eyes and airways. Follow the Safety Precaution guidance on this page together with the product SDS.
Why source Glibenclamide Sodium Salt from PYG Lifesciences?
When buyers compare pharmaceutical intermediates manufacturers, they usually look for three things: a clearly specified product, documents that are ready when needed, and people who understand the chemistry. With PYG you get all three, from a team that already knows the Glibenclamide chain through our Glibenclamide Sulfonamide.
Need more information?
Not sure whether our Glibenclamide Sodium Salt fits your process? Talk to our team about specifications, documents or bulk requirements. We’re glad to help.
