2-Butyl-4-Chloro-5-Formyl-1H-Imidazole (BCFI) Manufacturers in India
2-Butyl-4-Chloro-5-Formyl-1H-Imidazole
BCFI COMPOUNDS
2-Butyl-4-Chloro-5-Formyl-1H-Imidazole
- CAS No.: 83857-96-9
- Molecular formula: C₈H₁₁ClN₂O
- Molecular Weight: 186.64 g·mol⁻¹
- Application: Intermediate for antihypertensive APIs
- Specifications: Pharmaceutical intermediate grade
- Appearance: Off white to yellowish crystalline powder
- Storage: Room temperature (<25°C)
- Class: Pharmaceutical intermediate
Product overview
2-Butyl-4-Chloro-5-Formyl-1H-Imidazole (BCFI) is an intermediate employed in the synthesis of Losartan Potassium and other sartan-class APIs.
The compound is an imidazole-based building block used to enable controlled ring functionalization in downstream API synthesis when integrated into validated manufacturing workflows.
Key Applications of BCFI API Intermediate
Intermediate in Sartan Synthesis
Used as a precursor in the manufacture of Losartan Potassium and related sartan APIs; integration and yields depend on client process parameters.
Precursor for Imidazole-Derived APIs
Serves as a building block for other imidazole-structured pharmaceutical molecules across cardiovascular and metabolic therapy areas.
Research & Discovery
Used in medicinal chemistry and library synthesis for heterocyclic exploration where formyl and halo substituents enable further derivatisation.
Industrial Heterocyclic Synthesis
Adopted by chemical manufacturers for scalable synthesis of functionalised imidazole derivatives required in API and specialty chemical production.Technical Specifications of Our BCFI API Intermediate
| Sr. No. | Parameter | Details |
|---|---|---|
| 1 | Chemical Name | 2-Butyl-4-Chloro-5-Formyl-1H-Imidazole |
| 2 | Synonyms | BCFI; 2-Butyl-4-Chloro-5-Formylimidazole; 2-Butyl-5-Chloro-1H-Imidazole-4-Carboxaldehyde |
| 3 | CAS Number | 83857-96-9 |
| 4 | Molecular Formula | C₈H₁₁ClN₂O |
| 5 | Molecular Weight | 186.64 g·mol⁻¹ |
| 6 | Appearance | Off white to yellowish crystalline powder |
| 7 | Melting Point (Typical) | ~93–99°C |
Key Safety Information
- Strong skin sensitizer (allergic dermatitis risk)
- Eye irritant
- Toxic to aquatic life
This pharmaceutical intermediate is intended exclusively for industrial pharmaceutical manufacturing and research applications, particularly in the synthesis of SARTAN-class cardiovascular drugs. It is not intended for direct medicinal or human use.
Safety Precaution
- Prevent direct contact with skin and eyes
- Avoid releasing raw material or washings into drains/environment
- Wash thoroughly after handling
- Wear protective nitrile gloves, safety goggles, lab coat, and dust particulate mask (N95/FFP2)
- Keep container tightly closed in a cool, dry, well-ventilated area
- Inert atmosphere storage recommended to prevent degradation
Frequently Asked Questions (FAQs)
What is BCFI used for?
BCFI (2-Butyl-4-Chloro-5-Formyl-1H-Imidazole) is the imidazole intermediate used to manufacture Losartan Potassium, one of the most commonly prescribed blood pressure medications. It’s also used as a building block for other imidazole-derived cardiovascular APIs.
What is the CAS number and molecular formula of BCFI?
CAS 83857-96-9, molecular formula C₈H₁₁ClN₂O, molecular weight 186.64 g/mol. These three data points are enough to verify a supplier’s quotation against your own material specifications.
How do I know the BCFI I receive matches what's on the quotation?
Every shipment includes a batch-specific COA showing assay, appearance, and melting point (typically 93–99°C) against which you can verify the material on arrival. If your incoming QC doesn’t match the COA, PYG’s technical team will investigate the deviation directly.
Can I test a sample before committing to a bulk purchase?
Yes. Small sample quantities are available on request, subject to project qualification, so your lab can validate the material against your existing process before scaling to commercial volumes.
What's the typical lead time and minimum order quantity?
Reach out with your required volume for a specific lead time; it depends on batch scheduling and current order volume. Both sample-size and commercial bulk quantities can be accommodated, and the sales team will confirm MOQ and delivery timeline against your target date.
Do you export BCFI, and what documents are needed for customs/import?
Yes, exports are handled subject to contractual terms and destination-country regulatory requirements. Share your destination country with the team and they’ll confirm the export documentation (COA, SDS, HS code, and any additional certificates) needed for smooth customs clearance.
What happens if there's a quality issue with a delivered batch?
Every batch is QC-tested before dispatch, but if a discrepancy is found on your end, the technical team investigates against the retained sample and COA and resolves it per standard quality-complaint protocol. Contact the team with your batch number for the fastest turnaround.
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