High Purity. Trusted Bromo Compounds for Advanced Pharmaceutical Synthesis.
4'-Bromomethyl-2-cyanobiphenyl
Bromo-OTBN
4'-Bromomethyl-2-cyanobiphenyl
- CAS No.: 114772-54-2
- Molecular formula: C₁₄H₁₀BrN
- Molecular Weight: 272.14 g/mol
- Class: Brominated biphenyl nitrile intermediate
- Storage: Cool, dry place; protect from light and moisture
- Therapeutic uses: Used in the synthesis of Sartan group of drugs for treating hypertension.
Product overview
- Relaxing blood vessels
- Improving blood flow
- Reducing blood pressure
- Lowering risk of cardiovascular complications such as stroke and heart failure
Key Applications of Bromo-OTBN
Bromo-OTBN (4′-(bromomethyl)biphenyl-2-carbonitrile), synthesized via the bromination of o-tolylbenzonitrile (OTBN), is integral to several industries due to its reactive bromomethyl group and stable biphenyl framework. Here’s how it contributes to progress across sectors:
Pharmaceuticals
A vital intermediate in the production of APIs, especially in antihypertensive drug synthesis. Bromo-OTBN’s role in forming complex drug molecules makes it indispensable to modern medicine.
Specialty Chemicals & R&D
Labs and specialty chemical producers use Bromo-OTBN as a core building block to develop advanced compounds and formulations.
Agrochemical Intermediates
Though pharma-focused, Bromo-OTBN is also adapted in the development of selective agrochemical intermediates in certain formulations.
Other Industrial Uses
Its brominated nitrile structure makes it a suitable candidate in advanced material synthesis, polymers, and chemical engineering workflows.Used in manufacturing sartan-based medications, Bromo-OTBN serves as an essential intermediate in the synthesis of APIs such as candesartan, irbesartan, losartan, tasosartan, and valsartan.
Technical Specifications of Bromo-OTBN
| Sr. No. | Property | Details |
| 1 | Chemical Name | Bromo-OTBN (4′-Bromomethyl-2-cyanobiphenyl) |
| 2 | CAS Number | 114772-54-2 |
| 3 | Molecular Formula | C₁₄H₁₀BrN |
| 4 | Molecular Weight | 272.14 g/mol |
| 5 | Physical Form | Off-white to white powder with a fine consistency, optimized for ease of use |
| 6 | Grade | Industrial grade (COA available on request) |
| 7 | Purity | ≥ 98.0% (by HPLC) (or ≥ 99.0% (by HPLC) — confirm which spec applies to your Bromo-OTBN grade) |
| 8 | Stability | Stable under recommended storage conditions. Store in a cool, dry environment away from direct sunlight. |
All batches are tested in our QC laboratory per standard operating procedures (SOPs), with rigorous QA oversight prior to shipment.
| Specification | Details |
|---|---|
| Chemical Name | Bromo-OTBN (4’-Bromomethyl-2-cyanobiphenyl) |
| Synonyms | As used in client-specific synthetic routes |
| CAS Number | 114772-54-2 |
| Molecular Formula & Weight | C₁₄H₁₀BrN/272.14 g/mol |
| Appearance | Off-white to white powder with a fine consistency, optimized for ease of use in your processes. |
| Assay (HPLC) | NLT 98.0% (typical ≥99.0%) |
| Related Substances (HPLC) | Each ≤0.15%, total ≤0.50% or per customer-approved spec |
| Residual Solvents (GC) | In compliance with ICH Q3C |
| Water (KF) | ≤0.5–1.0% depending on processing and packaging |
| Melting Range | Provided on request |
| Retest Period | Up to 24 months under original sealed conditions (subject to stability data) |
| HS Code | Available upon request |
| Analytical Documentation | Complete IR, ¹H/¹³C NMR, MS, method summaries, impurity rationale, and stability data available under CDA/NDA |
| Grade | Industrial grade as per specification available. COA will be shared on request |
| Purity | Each batch is tested in our well-equipped QC laboratory by skilled analysts, following established SOPs and protocols. We ensure that the final product meets purity with rigorous QA oversight before shipment. |
| Stability | Stable under recommended storage conditions. We advise storage in a cool, dry environment away from direct sunlight. |
Key Safety Information
- Lachrymator (causes tearing/eye irritation)
- Severe skin sensitizer
- Respiratory tract irritant
This pharmaceutical intermediate is intended exclusively for industrial pharmaceutical manufacturing and research applications, particularly in the synthesis of SARTAN-class cardiovascular drugs. It is not intended for direct medicinal or human use.
Safety Precaution
- Handle strictly inside a certified fume hood or under local exhaust ventilation
- Avoid dust and vapor inhalation
- Wear chemical splash goggles/face shield, nitrile or neoprene chemical gloves, lab coat, and half-face particulate/organic vapor respirator
- Store in tightly sealed original containers in a cool, dry, dark place (below 25°C) away from moisture and heat
Frequently Asked Questions (FAQs)
What is Bromo-OTBN used for?
Bromo-OTBN is the key starting material (KSM) for sartan-class antihypertensive APIs, including Losartan, Valsartan, Irbesartan, and Candesartan. It forms the biphenyl-tetrazole core that gives these drugs their blood-pressure-lowering action.
What is the CAS number of Bromo-OTBN?
The CAS number of Bromo-OTBN is 114772-54-2. Also known as 4′-Bromomethyl-2-cyanobiphenyl, it is the key starting material (KSM) for Sartan-group cardiovascular APIs Losartan, Valsartan, Irbesartan, Candesartan, and Tasosartan. Molecular formula: C₁₄H₁₀BrN | Molecular weight: 272.14 g/mol
What is the difference between OTBN and Bromo-OTBN, and which one do I need?
OTBN is the methyl precursor compound, while Bromo-OTBN is its brominated derivative, the reactive form required for sartan API synthesis. If a supplier quotes you plain “OTBN” for a sartan project, confirm which form they mean before ordering, since it directly affects your downstream yield.
How do I verify the purity and quality before placing a bulk order?
Request a COA and, if needed, a small evaluation sample. PYG’s Bromo-OTBN is tested to NLT 98.0% assay by HPLC with a melting point of 105–110°C, and these figures should match what your incoming QC finds. Running this check before a full order avoids costly rework later.
What's the lead time for bulk quantities, and can capacity scale with my demand?
PYG operates commercial-scale manufacturing with surge capacity through parallel production trains, so monthly output can scale against your forecasted purchase orders. Share your expected volume and timeline with the sales team for an accurate delivery schedule.
How should I store Bromo-OTBN to maintain its shelf life?
Store at room temperature (below 25°C), away from moisture and direct sunlight, in the original sealed packaging. Handled this way, it carries a retest period of up to 24 months, subject to stability data. Re-test the material before use if a drum has been opened and stored for an extended period.
Can PYG customize packaging or handle smaller trial orders for new customers?
Yes. Standard commercial packaging comes in sealed drums, but smaller evaluation quantities can typically be arranged for new customers wanting to validate the material before committing to a full-scale order. Mention your requirement when requesting a quote.
Need more information?
