High Purity. Trusted Bromo Compounds for Advanced Pharmaceutical Synthesis.
BROMO COMPOUNDS
2-Cyano-4-Bromo Methyl Biphenyl
- CAS No.: 114772-54-2
- Molecular formula: C₁₄H₁₀BrN
- Molecular Weight: 272.14 g/mol
- Therapeutic uses: Hypertension
- Specifications: Pharmaceutical intermediate grade
- Appearance: Off-White Crystalline Powder
- Storage: Room temperature (<25°C)
- Class: Pharmaceutical intermediate
Product overview
- Relaxing blood vessels
- Improving blood flow
- Reducing blood pressure
- Lowering risk of cardiovascular complications such as stroke and heart failure
Key Applications of Bromo-OTBN
Bromo-OTBN, also known as o-Tolylbenzonitrile or 2-cyano-4-methylbiphenyl, is integral to several industries due to its
reactivity and stable structure. Here’s how it contributes to progress across sectors:
Pharmaceuticals
A vital intermediate in the production of APIs, especially in antihypertensive drug synthesis. Bromo-OTBN’s role in forming complex drug molecules makes it indispensable to modern medicine.
Specialty Chemicals & R&D
Labs and specialty chemical producers use Bromo-OTBN as a core building block to develop advanced compounds and formulations.
Agrochemical Intermediates
Though pharma-focused, Bromo-OTBN is also adapted in the development of selective agrochemical intermediates in certain formulations.
Other Industrial Uses
Its brominated nitrile structure makes it a suitable candidate in advanced material synthesis, polymers, and chemical engineering workflows.Used in manufacturing sartan-based medications, OTBN plays a vital role in drugs such as candesartan, irbesartan,
losartan, tasosartan, and valsartan, treatments for both high blood pressure and heart failure.
| Sr. No. | Property | Details | R&D, QC & QA observations |
| 1 | Chemical Name | Bromo-OTBN (4′-Bromomethyl-2-cyanobiphenyl) | OK |
| 2 | CAS Number | 114772-54-2 | typographical error |
| 3 | Molecular Formula | C₁₄H₁₀BrN | OK |
| 4 | Molecular Weight | 272.14 g/mol | OK |
| 5 | Physical Form | Off-white to white powder with a fine consistency, optimized for ease of use | OK |
| 6 | Grade | Industrial grade (COA available on request) | OK |
| 7 | Purity | Tested in QC laboratory per SOPs with rigorous QA oversight before shipment | OK |
| 8 | Stability | Stable under recommended storage conditions. Store in a cool, dry environment away from direct sunlight. | OK |
| Specification | Details |
|---|---|
| Chemical Name | Bromo-OTBN (4’-Bromomethyl-2-cyanobiphenyl) |
| Synonyms | As used in client-specific synthetic routes |
| CAS Number | 114772-54-2 |
| Molecular Formula & Weight | C₁₄H₁₀BrN/272.14 g/mol |
| Appearance | Off-white to white powder with a fine consistency, optimized for ease of use in your processes. |
| Assay (HPLC) | NLT 98.0% (typical ≥99.0%) |
| Related Substances (HPLC) | Each ≤0.15%, total ≤0.50% or per customer-approved spec |
| Residual Solvents (GC) | In compliance with ICH Q3C |
| Water (KF) | ≤0.5–1.0% depending on processing and packaging |
| Melting Range | Provided on request |
| Retest Period | Up to 24 months under original sealed conditions (subject to stability data) |
| HS Code | Available upon request |
| Analytical Documentation | Complete IR, ¹H/¹³C NMR, MS, method summaries, impurity rationale, and stability data available under CDA/NDA |
| Grade | Industrial grade as per specification available. COA will be shared on request |
| Purity | Each batch is tested in our well-equipped QC laboratory by skilled analysts, following established SOPs and protocols. We ensure that the final product meets purity with rigorous QA oversight before shipment. |
| Stability | Stable under recommended storage conditions. We advise storage in a cool, dry environment away from direct sunlight. |
Key Safety Information
- Use appropriate personal protective equipment (PPE) during handling
- Avoid inhalation of dust or direct skin/eye contact
- Handle in well-ventilated and controlled manufacturing environments
- Follow GMP-compliant material handling procedures
- Refer to Safety Data Sheet (SDS) for detailed handling and emergency guidance
Safety Precaution
- Handle only within certified pharmaceutical manufacturing facilities
- Ensure use of appropriate personal protective equipment (PPE) at all times
- Prevent direct exposure through inhalation, skin contact, or eye contact
- Maintain proper containment and follow established GMP protocols
- Dispose of material strictly in accordance with applicable regulatory and environmental guidelines
Frequently Asked Questions (FAQs)
Bromo-OTBN is the key starting material (KSM) for sartan-class antihypertensive APIs, including Losartan, Valsartan, Irbesartan, and Candesartan. It forms the biphenyl-tetrazole core that gives these drugs their blood-pressure-lowering action.
A Contract Manufacturing Organization (CMO) manufactures products using a customer-provided process, while a CDMO develops the process and manufactures it. PYG Lifesciences operates as a Contract Manufacturing Organization (CMO) focused on manufacturing execution and commercial supply.
OTBN is the methyl precursor compound, while Bromo-OTBN is its brominated derivative, the reactive form required for sartan API synthesis. If a supplier quotes you plain “OTBN” for a sartan project, confirm which form they mean before ordering, since it directly affects your downstream yield.
Request a COA and, if needed, a small evaluation sample. PYG’s Bromo-OTBN is tested to NLT 98.0% assay by HPLC with a melting point of 105–110°C, and these figures should match what your incoming QC finds. Running this check before a full order avoids costly rework later.
PYG operates commercial-scale manufacturing with surge capacity through parallel production trains, so monthly output can scale against your forecasted purchase orders. Share your expected volume and timeline with the sales team for an accurate delivery schedule.
Store at room temperature (below 25°C), away from moisture and direct sunlight, in the original sealed packaging. Handled this way, it carries a retest period of up to 24 months, subject to stability data. Re-test the material before use if a drum has been opened and stored for an extended period.
Yes. Standard commercial packaging comes in sealed drums, but smaller evaluation quantities can typically be arranged for new customers wanting to validate the material before committing to a full-scale order. Mention your requirement when requesting a quote.
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